Transplant
Effect of organ donor hospital volume on transplantable organs
Editor's Note Hospitals managing the highest volume of deceased organ donors were 52% more likely to recover an above-average number of transplantable organs per donor than low-volume hospitals in this study. The study included data from 4,427 donors across 384 hospitals. High-volume hospitals had an organ yield (ie, rate of…
Computer algorithm shows need for high-volume care for heart, lung transplant patients
Editor's Note Using a computerized mathematical model, Johns Hopkins researches investigated whether they could improve heart and lung transplants by transferring patients from low- to high-volume transplant centers. Among the findings: For heart transplants, 10 lives were saved after one center closure, and 240 lives were saved after up to…
First clinical trial of HCV-infected kidney transplants
Editor's Note Researchers at Penn Medicine, Philadelphia, are conducting a clinical trial to test the effect of administering antiviral therapy to organ recipients after being transplanted with kidneys infected with the hepatitis C virus (HCV). The first participant received a kidney transplant in July, and after being treated with Zepatier…
Growing number of sickest patients removed from liver transplant wait list
Editor's Note Liver transplant candidates who are the sickest and should be first in line for a donor liver are increasingly being removed from the wait list because they are considered too sick to transplant, finds this study. Between 2007 and 2012, more than 4,300 patients were taken off the…
Organ recipients with previous cancers have higher rates of mortality, new cancers
Editor's Note In this meta-analysis, organ recipients who had cancer before receiving an organ transplant had higher rates of mortality and new cancers than organ recipients who had not had cancer. Organ recipients with previous cancers had a 1.5 times greater risk of dying from any cause, 3 times higher…
Surgeons to use HCV infected kidneys for transplant
Editor's Note Surgeons at the University of Pennsylvania and Johns Hopkins University hospitals will transplant kidneys from donors with hepatitis C virus (HCV) as part of a clinical trial this spring, STAT news reports. The recipients will be given a 12-week course of antiviral therapy after the transplant in hopes…
Kidney transplants from incompatible live donors tied to significant survival benefit
Editor's Note Patients who underwent desensitization therapy and received kidney transplants from HLA-incompatible live donors had a substantial survival benefit, compared with patients who did not undergo transplantation or those who waited for transplants from deceased donors, this study finds. Researchers from Johns Hopkins, Baltimore, enrolled 1,025 patients at 22…
Donor organ recovery at freestanding facility increases organ yield, lowers costs
Editor's Note Obtaining organs from deceased donors in a freestanding facility dedicated to organ recovery costs much less and leads to higher numbers of transplantable organs, this study finds. Researchers evaluated 6 years of data from the nation’s first freestanding organ recovery facility located in St Louis and owned and…
Cleveland Clinic performs first uterus transplant
Editor's Note A team of Cleveland Clinic surgeons on February 24 performed the nation’s first uterus transplant. The 9-hour procedure was performed on a 26-year old patient who had uterine factor infertility. The transplanted uterus came from a deceased organ donor. Further information will be released this week in a…
Johns Hopkins approved for first HIV-positive organ transplants
Editor's Note Johns Hopkins Hospital, Baltimore, is the first and only center in the US to be approved by the United Network for Organ Sharing to perform HIV-positive to HIV-positive organ transplants. The hospital will be the first in the nation to do an HIV-positive to HIV-positive kidney transplant and…
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