March 6, 2024

Negative pressure wound therapy reduces SSI across surgical specialties

Editor's Note

Compared with standard wound dressings, single-use negative pressure wound therapy (NPWT) devices can reduce the incidence of surgical site infection (SSI) in at-risk patients with closed surgical incisions across a range of surgical specialties, according to a data review highlighted in the February issue of the American Journal of Surgery.

Originally published online October 23, the systematic literature review and meta-analysis identified 15,283 articles posted to PubMed, Embase, Cochrane Library and from January 2011 to April 2021. Out of that total, it included 19 articles. “A statistically significant improvement (p ​< ​0.05) in the composite SSI (odds ratio [OR]: 0.36; 95 ​% confidence interval [CI]: 0.27–0.49), superficial SSI (OR: 0.30; 95 ​% CI: 0.17–0.53), and deep SSI (OR: 0.67; 95 ​% CI: 0.46–0.96) outcomes was observed with the sNPWT device compared with standard care in a pooled analysis of all surgical specialties,” researchers wrote.

Specific highlights include:

Surgical site infection is a clinically important complication with high morbidity.

  • -80 ​mmHg sNPWT significantly reduces the incidence of deep SSI.
  • -80 ​mmHg sNPWT significantly reduces SSI in Class I and Class II surgeries.
  • -80 ​mmHg sNPWT is effective at reducing SSI in a range of surgical specialties.
  • No significant difference was observed with sNPWT and SoC for organ-space SSI.


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