Editor's Note This study led by researchers at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, finds that more severe acute COVID-19 illness, a higher Charlson Comorbidity Index (CCI) score, and being unvaccinated before infection were linked to a higher risk of reporting 28 days or more of…

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Editor's Note This study by researchers from the Icahn School of Medicine at Mount Sinai, New York City, is one of the first to link long COVID symptoms at more than 1 year with changes in gene expression that occurred during the acute stage of COVID-19. The researchers examined blood…

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Editor's Note This study from Spain finds that 59.7% of hospitalized and 67.5% of nonhospitalized COVID-19 patients had at least one symptom 2 years after infection. Of 360 hospitalized and 308 nonhospitalized COVID-19 patients analyzed, fatigue (161 vs 147), pain (129 vs 92), and memory loss (72 vs 49) were…

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Editor's Note This French study finds that persistent symptoms were still present in 10.1% of COVID-19 infected individuals at 1 year. Of 53,047 study participants analyzed, 3,972 (2,531 women) with a mean age of 50.9 years had been infected with COVID-19. Of these, 2,647 reported at least one symptom during…

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Editor's Note This study led by researchers at the VA Puget Sound Health Care System and University of Washington, Seattle, highlights the complexity of diagnosing long COVID and the challenges of caring for patients with this condition. Included in the analysis were 200 randomly sampled COVID-19 patients receiving care in…

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Editor's Note JAMA Network published a research article on October 27 showing the long-term effects of COVID-19 on adults in the US and evaluating vaccine effectiveness for lasting symptoms, Health Leaders Media October 28 reports. The World Health Organization defines symptoms that last for at least 2 months post-infection as…

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Editor's Note This study by the Global Burden of Disease Long COVID Collaborators estimates that the proportion of patients with at least one of three long-COVID-19 symptoms (persistent fatigue with bodily pain or mood swings, cognitive problems, or ongoing respiratory problems) 3 months after COVID-19 infection is 6.2%. Analyzing 54…

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Editor's Note This Canadian study finds that most COVID-19 patients recover within 12 months, irrespective of severity. Researchers surveyed 106 patients recovering from COVID-19 at 3-, 6-, and 12 months. A total of 75% had recovered at the 12-month mark, but 25% still had at least one of three common…

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Editor's Note In this study from Brazil, researchers find that olfactory dysfunction (ie, reduced or distorted ability to smell during sniffing or eating) in patients with long COVID-19 may persist for more than 1 year and may become permanent. Of 219 patients (164 [74.9%] women) with long COVID-19 and neurologic…

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Editor's Note A new Harvard study published Wednesday, September 7, in JAMA Psychiatry finds that people who felt stressed, anxious, lonely, depressed or worried about getting infected with COVID-19 were at higher risk of developing long-term symptoms, NBC September 8 reports. The study looked at survey responses from nearly 55,000…

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