March 13, 2019

IV and oral acetaminophen work equally well after THA

By: Judy Mathias

Editor's Note

Intravenous (IV) acetaminophen did not result in a significant difference in pain scores, opioid consumption, or opioid-related adverse events compared with oral acetaminophen, finds this study presented March 12 at the American Academy of Orthopaedic Surgeons Annual Meeting in Las Vegas.

A total of 154 patients having total hip arthroplasty (THA) were randomized to receive postoperative oral acetaminophen with an IV placebo or IV acetaminophen with an oral placebo.

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Patients in both groups:

  • had low pain scores
  • had a low burden of opioid-related adverse events
  • used modest amounts of opioids, corresponding to 6 doses of tramadol 100 mg over 3 days.

The findings support the use of oral acetaminophen, which is less costly and less invasive to administer, the authors say.


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