Pembrolizumab sets new standard in advanced head and neck cancer surgery, trial shows
Editor's Note According to results from a randomized trial, titled KEYNOTE-689, adding pembrolizumab (Keytruda) to surgery and standard adjuvant therapy significantly prolongs event-free survival (EFS) in patients with resectable, locally advanced head and neck squamous cell carcinoma (HNSCC), MedPage Today April 28 reports. Experts are calling the findings a major…
Study: Microglia help awaken the brain from anesthesia, protect neurons from aftereffects
Editor's Note A new study finds that the same cells that are involved in preventing damage to the central nervous system – called microglia – help to awaken the brain following anesthesia. The findings appeared January 4 in the journal Nature. Using electron-microscopy-based synaptic reconstruction, the researchers could see the…
Researchers identify immunity-driven factors behind rejection of medical implants
Editor's Note Medical devices such as pacemakers, breast implants, or knee replacements often cause hostile immune responses that can damage not only the implants but also surrounding tissue in the patient. That rejection often leads to further intervention needed that may include medications such as immunosuppressants or additional procedures. Researchers…
Study: Consistent lack of sleep impacts immune cells
Editor's Note This study from the Icahn School of Medicine at Mount Sinai, New York City, finds that chronic, insufficient sleep can negatively affect immune cells, which may lead to inflammatory disorders and cardiovascular disease. Immune cells fight infection, but if the numbers get too high, they overreact and cause…
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