Editor's Note
The World Health Organization on March 30 reported that although there is an overall downward trend in COVID-19 cases and deaths, 21 countries are reporting increases in cases of Omicron subvariant XBB.1.16, particularly India.
XBB.1.16 has a similar profile to XBB.1.5, which is the dominant strain in the US, but it has three additional mutations in the SARS-CoV-2 spike protein, with one that has shown increased infectivity and a potential increase in pathogenicity in lab studies.
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