Study examines relationship between personalized prehabilitation and modulation of peripheral immune system

A newly published randomized clinical trial conducted by Stanford University School of Medicine and colleagues from France examines the question, “How do personalized prehabilitation programs modulate the peripheral immune system in patients undergoing major elective surgery?”

In the trial, 58 patients who were scheduled for major elective surgery received either personalized or standard prehabilitation. “High-dimensional immune profiling with mass cytometry revealed profound and cell type-specific dampening of proinflammatory signaling responses in the personalized prehabilitation group but not in the standard group,” the researchers write. “Patients in the personalized prehabilitation group also showed significant improvements in both physical and cognitive function, with significantly fewer severe postoperative complications.”

The researchers say their findings suggest that “tailored interventions may optimize surgical preparedness and reduce complications… These findings support the use of personalized prehabilitation and provide an avenue for biologically driven monitoring of prehabilitation efficacy, and individual tailoring of programs to optimize surgical readiness and recovery.”

Read the full study, published on JAMA Network, here.