March 30, 2020

Treatment of critically ill COVID-19 patients with convalescent plasma

By: Judy Mathias

Editor's Note

In this preliminary uncontrolled case series of five critically ill COVID-19 and acute respiratory distress syndrome (ARDS) patients, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status.

All five patients (age 36-65 years, 2 women and 3 men) were on mechanical ventilation, and all had received antiviral agents and methylprednisolone.

Sponsored Message

After plasma transfusion:

  • body temperature normalized within 3 days in four patients
  • Sequential Organ Failure Assessment (SOFA) score decreased
  • ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) increased within 12 days
  • viral loads decreased and became negative within 12 days
  • ARDS resolved in 4 patients at 12 days
  • 3 patients were weaned from mechanical ventilation within 2 weeks.

Of the five patients, three have been discharged (length of stay: 53, 51, and 55 days), and two are in stable condition at 37 days after plasma transfusion.

The findings require evaluation in clinical trials, the researchers note.


Sign Up For OR a.m.
Sign up for the free OR a.m. eLetter to get news like this in your inbox every morning!

OR Manager Jobs
Live chat by BoldChat