July 13, 2020

COVID-19 pathophysiology, transmission, diagnosis, treatment

By: Judy Mathias

Editor's Note

In this review article, researchers from the US, UK, Netherlands, and Australia discuss current evidence on the pathophysiology, transmission, diagnosis, and management of COVID-19.

Among their findings:

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  • COVID-19 is spread primarily via respiratory droplets during close face-to-face contact.
  • Infection can be spread by asymptomatic, presymptomatic and symptomatic carriers.
  • The average time from exposure to symptom onset is 5 days, and 97.5% of people who develop symptoms do so within 11.5 days
  • The most common symptoms are fever, dry cough, and shortness of breath.
  • Diagnosis is made by detection of the virus via reverse transcription polymerase chain reaction testing, though false-negative test results occur in 20% to 67% of patients.
  • About 5% of patients with COVID-19 and 20% of those hospitalized have severe symptoms necessitating intensive care.
  • More than 75% of COVID-19 patients who are hospitalized require supplemental oxygen.
  • Dexamethasone reduces 28-day mortality in patients requiring oxygen compared with usual care (21.6% vs 24.6%).
  • Remdesivir improves time to recovery from 15 to 11 days.
  • Convalescent plasma did not shorten time to recovery.
  • Mortality varies by age, ranging from 0.3 deaths/1,000 cases for patients aged 5 to 17 years to 304.9 deaths/1,000 cases for patients aged 85 years or older.

As of July 1, 2020, many aspect of transmission, infection, and treatment of COVID-19 remains unclear, the researchers say. Nearly 120 human vaccines are currently under development, and more than a dozen are being tested in phase 1-3 trials.



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August 2020

Lean and Patient Safety: The Perfect Perioperative Partners

Wednesday, July 29, 2020 | 12:00 p.m. – 1:00 p.m. ET | 1 CE

Unprecedented times present unique opportunities. We all know how the pandemic has disrupted perioperative and elective services. The pandemic is challenging us, but it has also presented us with an opportunity to evaluate many processes during the re-start of surgical service lines. As you re-deploy you will find many opportunities for improvement. You have the ability with the right approach to improve quality, staff and surgeon satisfaction, patient satisfaction, flow, and expense.

How do you take advantage of this moment in time to identify the challenges that have plagued your OR for years, create logical plans, and finally implement solutions that work? During this free webinar, we will share Lean tools and methodologies that can help you attain a future state that is better than the pre-pandemic normal. You will learn straightforward Lean practices, tips, and tools that can help you improve perioperative services for the benefit of all. Discussion will also include case study examples of how Lean thinking can work to improve the effectiveness of your OR, every day, for everyone.

Learning Objectives:

  1. Recognize the opportunities for perioperative services improvement now and moving forward through the pandemic.
  2. Learn about Lean methodology and tools that can be deployed in any OR and SPD.
  3. Understand from case study examples how successful Lean interventions can be implemented and consistently reproduced.

Can’t make it? This webinar will be made available on-demand for you to access at your convenience, but you will still need to register.

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