April 7, 2021

Aspirin use linked to improved outcomes in COVID-19 patients

By: Judy Mathias
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Editor's Note

This multicenter retrospective study led by researchers from George Washington University School of Medicine, Washington, DC, found that aspirin use by COVID-19 patients was associated with improved outcomes.

Of 412 COVID-19 patients included in the study, 314 (76.3%) did not receive aspirin, and 98 (23.7%) received aspirin within 24 hours of admission or 7 days before admission.


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Aspirin was associated with less mechanical ventilation (35.7% aspirin vs 48.4% nonaspirin) and ICU admission (38.8% aspirin vs 51.0% nonaspirin), but not with in-hospital mortality (26.5% aspirin vs 23.2% nonaspirin).

After controlling for confounding variables, aspirin use was associated with a significantly deceased risk for mechanical ventilation, ICU admission, and in-hospital mortality.

There were no significant differences in major bleeding (6.1% vs 7.6%) or overt thrombosis (8.2% vs 8.9%) between aspirin and nonaspirin users.

The researchers concluded that a randomized controlled trial is needed to assess whether a causal relationship exists between aspirin use and reduced lung injury and mortality in COVID-19 patients.

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